Heavy-ion effects: from track structure to DNA and chromosome damage

Heavy-ion effects: from track structure to DNA and chromosome damage

The use of carbon ions for the treatment of certain tumour types, especially radioresistant tumours, is becoming more frequent due to the carbonion dose localization and high relative biological effectiveness (RBE) in the Bragg peak region. Human beings can also be exposed to heavy ions in space, since galactic cosmic rays are a mixed field consisting of not only high-energy protons and He ions...

Radiation track and DNA damage

Track “Core” Effects in Heavy Ion Radiolysis

By assuming that HO2 ● radical production in water and H2 production in benzene are 2 hit processes, and applying the concepts of track physics, we are able to obtain a parametric fit to the yields of these reactions by heavy ion radiolysis from knowledge of the radial dose distribution about a heavy ion’s path. We make no use of the concept of a track core, for no clearly definable track core ...

radiation track and dna damage

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Radiation track and DNA damage

hisarticle provides a brief review of aspects of biophysical modelling in radiation biology. A major concern of radiation biology in the past half century has been the quantification of the health hazards of ionising radiations of different qualities and extrapolation of human cancer risks at high dose and dose rates to low dose and dose rates (UNSCEAR 1993). In the past decade with the acceler...